An X3D Neural Network Analysis for Runner's Performance Assessment in a Wild Sporting Environment

We present a transfer learning analysis on a sporting environment of the expanded 3D (X3D) neural networks. Inspired by action quality assessment methods in the literature, our method uses an action recognition network to estimate athletes' cumulative race time (CRT) during an ultra-distance competition. We evaluate the performance considering the X3D, a family of action recognition networks that expand a small 2D image classification architecture along multiple network axes, including space, time, width, and depth. We demonstrate that the resulting neural network can provide remarkable performance for short input footage, with a mean absolute error of 12 minutes and a half when estimating the CRT for runners who have been active from 8 to 20 hours. Our most significant discovery is that X3D achieves state-of-the-art performance while requiring almost seven times less memory to achieve better precision than previous work.Comment: Accepted to the 18th International Conference on Machine Vision Applications (MVA 2023

European Strategies for Adaptation to Climate Change with the Mayors Adapt Initiative by Self-Organizing Maps

Featured Application: The methodology developed in this research has direct application in understanding European initiatives and policies for adaptation to climate change through the identification of differentiated strategic adaptation frameworks.The European Union (EU) has assigned municipal governments a key role in the transformations needed to achieve its climate and energy objectives. One of the main initiatives of the EU has been the “The Covenant of Mayors”, launched in 2008, with impacts beyond Europe due to integration with the “Global Covenant of Mayors for Climate and Energy”. This research focuses on local measures to adapt to climate change, verifying their differences between themselves, and aims to identify and characterize patterns in the different adaptation strategies examined. Further aims are (i) the collection of good practices, framed in the Mayors Adapt initiative, managing multidimensional data from the context and from its adaptation proposals; (ii) the classification of strategies in profiles and patterns using artificial neural networks based on the previous variables; (iii) the characterization and comparison of such profiles. The results substantiate the existence of several well-differentiated approaches, connected with their geographical context, vulnerability and politics. These results provide valuable information for its interpretation and for the planning of climate change adaptation actions, highlighting the value of the creation of networks of institutional collaboration targeted at each strategic framework.This research was funded by Consejería de Economía, Innovación, Ciencia y Empleo, Andalusian Regional Government (Spain) grant number P12-RNM-1514. And The APC was funded by University of Granada (Spain)

The JAK3Q988P mutation reveals oncogenic potential and resistance to ruxolitinib

T-cell acute lymphoblastic leukemia (T-ALL) arises from the malignant transformation of T-cell progenitors at various differentiation stages. Given that patients who relapse have a dismal prognosis, there is an urgent need to identify the molecular alterations that are present in such patients and promote leukemogenesis to implement personalized therapies with higher efficacy and fewer adverse effects. In the present manuscript, we identified the JAK3Q988P mutation in a T-ALL patient who did not achieve a durable response after the conventional treatment and whose tumor cells at relapse presented constitutive activation of the JAK/STAT pathway. Although JAK3Q988P has been previously identified in T-ALL patients from different studies, the functional consequences exerted by this mutation remain unexplored. Through the combination of different hematopoietic cellular models, we functionally characterize JAK3Q988P as an oncogenic mutation that contributes to leukemogenesis. Notably, JAK3Q988P not only promotes constitutive activation of the JAK/STAT pathway in the absence of cytokines and growth factors, as is the case for other JAK3 mutations that have been functionally characterized as oncogenic, but also functions independently of JAK1 and IL2RG, resulting in high oncogenic potential as well as resistance to ruxolitinib. Our results indicate that ruxolitinib may not be efficient for future patients bearing the JAK3Q988P mutation who instead may obtain greater benefits from treatments involving other pharmacological inhibitors such as tofacitinib.This work was supported in part by funds from Ministerio de Economía y Competitividad (SAF2015‐70561‐R; MINECO/FEDER, EU to J.F.‐P. and M.V.‐M.); Ministerio de Ciencia, Innovación y Universidades (RTI2018‐093330‐B‐I00; MCIU/FEDER, EU to J.F.‐P. and J.S.); Fundación Ramón Areces (CIVP19S7917 to J.F.‐P.); Comunidad de Madrid (B2017/BMD‐3778; LINFOMAS‐CM to J.F.‐P.); Asociación Española Contra el Cáncer (AECC, 2018; PROYE18054PIRI to J.F.‐P.);and Instituto de Investigación Sanitaria Fundación Jiménez Díaz to J.F.‐P.;institutional grants from the Fundación Ramón Areces and Banco de Santander to the CBMSO are also acknowledged.S

Influence of the type of physician on survival from emergency-medical-service-witnessed cardiac arrest: an observational study

Out-of-hospital cardiac arrest resuscitation by non-emergency dedicated physicians may not be positively associated with survival, as these physicians have less experience and exposure than specialised dedicated personnel. The aim of this study was to compare the survival results of the teams led by emergency dedicated physicians (EDPhy) with those of the teams led by non-emergency dedicated physicians (N-EDPhy) and with a team of basic life support (BLS) emergency technicians (EMTs) used as the control group. A retrospective, multicentre study of emergency-medical-servicewitnessed cardiac arrest from medical causes in adults was performed. The records from 2006 to 2016 in a database of a regional emergency system were analysed and updated up to 31 December 2021. Two groups were studied: initial shockable and non-shockable rhythms. In total, 1359 resuscitation attempts were analysed, 281 of which belonged to the shockable group, and 1077 belonged to the non-shockable rhythm group. Any onsite return of spontaneous circulation, patients admitted to the hospital alive, global survival, and survival with a cerebral performance category (CPC) of 1-2 (good and moderate cerebral performance) were studied, with both of the latter categories considered at 30 days, 1 year (primary outcome), and 5 years. The shockable and non-shockable rhythm group (and CPC 1-2) survivals at 1 year were, respectively, as follows: EDPhy, 66.7 % (63.4%) and 14.0% (12.3%); N-EDPhy, 16.0% (16.0%) and 1.96 % (1.47%); and EMTs 32.0% (29.7%) and 1.3% (0.84%). The crude ORs were EDPhy vs. N-EDPhy, 10.50 (5.67) and 8.16 (4.63) (all p < 0.05); EDPhy vs. EMTs, 4.25 (2.65) and 12.86 (7.80) (p 0.05). The presence of an EDPhy was positively related to all the survival and CPC ratesS

Personal Guides: Heterogeneous Robots Sharing Personal Tours in Multi-Floor Environments

GidaBot is an application designed to setup and run a heterogeneous team of robots to act as tour guides in multi-floor buildings. Although the tours can go through several floors, the robots can only service a single floor, and thus, a guiding task may require collaboration among several robots. The designed system makes use of a robust inter-robot communication strategy to share goals and paths during the guiding tasks. Such tours work as personal services carried out by one or more robots. In this paper, a face re-identification/verification module based on state-of-the-art techniques is developed, evaluated offline, and integrated into GidaBot’s real daily activities, to avoid new visitors interfering with those attended. It is a complex problem because, as users are casual visitors, no long-term information is stored, and consequently, faces are unknown in the training step. Initially, re-identification and verification are evaluated offline considering different face detectors and computing distances in a face embedding representation. To fulfil the goal online, several face detectors are fused in parallel to avoid face alignment bias produced by face detectors under certain circumstances, and the decision is made based on a minimum distance criterion. This fused approach outperforms any individual method and highly improves the real system’s reliability, as the tests carried out using real robots at the Faculty of Informatics in San Sebastian show.This work has been partially funded by the Basque Government, Spain, grant number IT900-16, and the Spanish Ministry of Economy and Competitiveness (MINECO), grant number RTI2018-093337-B-I00

Biocarbonates Derived from CO2 and Terpenes: Molecular Design for Aqueous Mixture Treatment Driven by COSMO-RS

In this work, the use of plant-derived raw materials, such as terpenes, gives great strength from a sustainability perspective and enables dealing with the biocarbonate concept. Biocarbonates are produced only from CO2and residues or bio-derived compounds, describing cycloaddition reactions that couple CO2and a terpene, the latter after epoxidation, avoiding environmental charges from petroleum-derived epoxides. In this work, a comprehensive database (derived from 30 terpenes) accounting bioepoxides and corresponding biocarbonates was developed, by means of molecular simulation. Optimized structures realized by the DFT method allow using a priori tools to scan the possible applications of this new class of sustainable solvents. Using a COnductor-like Screening Model for Realistic Solvents, different biocarbonates were evaluated for their physical properties and capacity to remove value-Added or contaminant solutes from aqueous mixtures, namely, furfural, phenolic compounds, and volatile fatty acids. It was found that biocarbonates derived from terpenes generally present a higher affinity for solutes in comparison with neat terpenes. Indeed, biocarbonates allowed achieving the recovery of 99% of phenol, 98% of furfural, and 87% of acetic acid, also pointing to an advantageous scenario of higher boiling points and densities and comparable solvent losses in the aqueous phase to terpenesThe authors are grateful to Ministerio de Ciencia e Innovación of Spain (projects PID2020-118259RB-I00 and PDC2021- 120881-I00) and Comunidad de Madrid (project P2018/ EMT4348) for financial support and Centro de Computación Científica de la Universidad Autónoma de Madrid for computational facilities. E.H. thanks Spanish Ministerio de Universidades for awarding an FPU grant FPU20/03198. R.S. thanks Ministerio Universidades for his Margarita Salas contract (CA1/RSUE/2021-00585

MONOS: Multiplicity of Northern O-type Spectroscopic systems: I. Project description and spectral classifications and visual multiplicity of previously known objects

Context. Multiplicity in massive stars is key to understanding the chemical and dynamical evolution of galaxies. Among massive stars, those of O type play a crucial role due to their high masses and short lifetimes. Aims. MONOS (Multiplicity Of Northern O-type Spectroscopic systems) is a project designed to collect information and study O-type spectroscopic binaries with δ > −20◦ . In this first paper we describe the sample and provide spectral classifications and additional information for objects with previous spectroscopic and/or eclipsing binary orbits. In future papers we will test the validity of previous solutions and calculate new spectroscopic orbits. Methods. The spectra in this paper have two sources: the Galactic O-Star Spectroscopic Survey (GOSSS), a project that obtains blueviolet R ∼ 2500 spectroscopy of thousands of massive stars, and LiLiMaRlin, a library of libraries of high-resolution spectroscopy of massive stars obtained from four different surveys (CAFÉ-BEANS, OWN, IACOB, and NoMaDS) and additional data from our own observing programs and public archives. We have also used lucky images obtained with AstraLux. Results. We present homogeneous spectral classifications for 92 O-type spectroscopic multiple systems and ten optical companions, many of them original. We discuss the visual multiplicity of each system with the support of AstraLux images and additional sources. For eleven O-type objects and for six B-type objects we present their first GOSSS spectral classifications. For two known eclipsing binaries we detect double absorption lines (SB2) or a single moving line (SB1) for the first time, to which we add a third system reported by us recently. For two previous SB1 systems we detect their SB2 nature for the first time and give their first separate spectral classifications, something we have also done for a third object just recently identified as a SB2. We also detect nine new astrometric companions and provide updated information on several others. We emphasize the results for two stars: for σ Ori AaAbB we provide spectral classifications for the three components with a single observation for the first time thanks to a lucky spectroscopy observation obtained close to the Aa,Ab periastron and for θ 1 Ori CaCb we add it to the class of Galactic Of?p stars, raising the number of its members to six. Our sample of O-type spectroscopic binaries contains more triple- or higher-order systems than double systems.Fil: Maíz Apellániz, Jesús. Consejo Superior de Investigaciones Cientificas. Instituto Nacional de Tecnica Aeroespacial.; EspañaFil: Trigueros Páez, E.. Consejo Superior de Investigaciones Cientificas. Instituto Nacional de Tecnica Aeroespacial.; España. Universidad de Alicante; EspañaFil: Negueruela, Ignacio. Universidad de Alicante; EspañaFil: Barbá, Rodolfo. Universidad de La Serena; ChileFil: Simón Díaz, S.. Instituto Astrofisico de Canarias; España. Universidad de La Laguna; EspañaFil: Lorenzo, Javier. Universidad de Alicante; EspañaFil: Sota, Alfredo. Instituto de Astrofísica de Andalucía; EspañaFil: Gamen, Roberto Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Fariña, Cecilia. Instituto de Astrofísica de Canarias; España. Isaac Newton Group of Telescopes; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Salas, J.. Agrupación Astronómica de Huesca; EspañaFil: Caballero, Javier Alberto. Consejo Superior de Investigaciones Cientificas. Instituto Nacional de Tecnica Aeroespacial.; EspañaFil: Morrell, Nidia Irene. Las Campanas Observatory; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Pellerin, Anne. State University of New York; Estados UnidosFil: Alfaro Navarro, Emilio Javier. Instituto de Astrofísica de Andalucía; EspañaFil: Herrero, Artemio. Instituto de Astrofísica de Canarias; España. Universidad de La Laguna; EspañaFil: Arias, Julia Ines. Universidad de La Serena; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Marco, Amparo. Universidad de Alicante; Españ

Multitemporal monitoring of plant area index in the Valencia Rice District with PocketLAI

Leaf area index (LAI) is a key biophysical parameter used to determine foliage cover and crop growth in environmental studies in order to assess crop yield. Frequently, plant canopy analyzers (LAI-2000) and digital cameras for hemispherical photography (DHP) are used for indirect effective plant area index (PAIeff ) estimates. Nevertheless, these instruments are expensive and have the disadvantages of low portability and maintenance. Recently, a smartphone app called PocketLAI was presented and tested for acquiring PAIeff measurements. It was used during an entire rice season for indirect PAIeff estimations and for deriving reference high-resolution PAIeff maps. Ground PAIeff values acquired with PocketLAI, LAI-2000, and DHP were well correlated (R2 = 0.95, RMSE = 0.21 m2/m2 for Licor-2000, and R2 = 0.94, RMSE = 0.6 m2/m2 for DHP). Complementary data such as phenology and leaf chlorophyll content were acquired to complement seasonal rice plant information provided by PAIeff. High-resolution PAIeff maps, which can be used for the validation of remote sensing products, have been derived using a global transfer function (TF) made of several measuring dates and their associated satellite radiances

RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

BACKGROUND: Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis in these malignancies that is primarily attributed to loss of CDKN2A (encoding protein p16INK4A). However, the impact of the deregulation of other genes such as CDKN1C, E2F1, and TP53 remains to be clarified. Interestingly, experiments in mouse models have proven that conditional T-cell specific deletion of Cdkn1c gene may induce a differentiation block at the DN3 to DN4 transition, and that the loss of this gene in the absence of Tp53 led to aggressive thymic lymphomas. RESULTS: In this manuscript, we demonstrated that the simultaneous deregulation of CDKN1C, E2F1, and TP53 genes by epigenetic mechanisms and/or the deregulation of specific microRNAs, together with additional impairing of TP53 function by the expression of dominant-negative isoforms are common features in primary human T-LBLs. CONCLUSIONS: Previous experimental work in mice revealed that T-cell specific deletion of Cdkn1c accelerates lymphomagenesis in the absence of Tp53. If, as expected, the consequences of the deregulation of the CDKN1C-E2F1-TP53 axis were the same as those experimentally demonstrated in mouse models, the disruption of this axis might be useful to predict tumor aggressiveness, and to provide the basis towards the development of potential therapeutic strategiesin human T-LBL.The authors would like to thank the Spanish Ministry of Economy and Competitiveness (SAF2015–70561-R; MINECO/FEDER, EU) and the Autonomous Community of Madrid, Spain (B2017/BMD-3778; LINFOMAS-CM) for funding this work. Institutional grants from the Fundación Ramón Areces and Banco de Santander are also acknowledged.S